Background Major depressive disorder (MDD) affects women approximately twice as often
as men. Women are three times as likely to have atypical depression, with hypersomnia and
weight gain. This suggests that the molecular mechanisms of MDD may differ by sex.
Methods To test this hypothesis, we performed a large-scale gene expression meta-analysis
across three corticolimbic brain regions: the dorsolateral prefrontal cortex, subgenual
anterior cingulate cortex, and basolateral amygdala (26 men, 24 women with MDD and sex�…