Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women
S Hulley, D Grady, T Bush, C Furberg, D Herrington…�- Jama, 1998 - jamanetwork.com
Context.—Observational studies have found lower rates of coronary heart disease (CHD) in
postmenopausal women who take estrogen than in women who do not, but this potential
benefit has not been confirmed in clinical trials. Objective.—To determine if estrogen plus
progestin therapy alters the risk for CHD events in postmenopausal women with established
coronary disease. Design.—Randomized, blinded, placebo-controlled secondary prevention
trial. Setting.—Outpatient and community settings at 20 US clinical centers. Participants.—A�…
postmenopausal women who take estrogen than in women who do not, but this potential
benefit has not been confirmed in clinical trials. Objective.—To determine if estrogen plus
progestin therapy alters the risk for CHD events in postmenopausal women with established
coronary disease. Design.—Randomized, blinded, placebo-controlled secondary prevention
trial. Setting.—Outpatient and community settings at 20 US clinical centers. Participants.—A�…