Polycystic ovarian syndrome (PCOS) is a common disorder characterized by ovulatory
dysfunction and hyperandrogenemia (HA). Neuroendocrine abnormalities including
increased gonadotropin-releasing hormone (GnRH) pulse frequency, increased luteinizing
hormone (LH) pulsatility, and relatively decreased follicle stimulating hormone contribute to
its pathogenesis. HA reduces inhibition of GnRH pulse frequency by progesterone, causing
rapid LH pulse secretion and increasing ovarian androgen production. The origins of�…