RESULTS

Histologicalfindings. The characteristic features, argentifhe plaques and fibrillary changes, of Alzheimer's disease were most prominent in the frontal and temporal cortex. Histologically demonstrable iron was regularly found in fairly large amounts in these regions (see Table 1). Up to the present we have not been able to find iron in histological sections from the frontal and temporal cortex of normal brains (HALLGRBN and SOURANDEX, 1958). Considerable amounts of iron were detected in the motor and occipital cortex in the cases of Alzheimer's disease. In normal brains of old people minimal amounts of iron were found in the motor and occipital cortex