[HTML][HTML] Acetyl-CoA carboxylase 2−/− mutant mice are protected against fatty liver under high-fat, high-carbohydrate dietary and de novo lipogenic conditions
L Abu-Elheiga, H Wu, Z Gu, R Bressler…�- Journal of Biological�…, 2012 - ASBMB
Hepatic fat accumulation resulting from increased de novo fatty acid synthesis leads to
hepatic steatosis and hepatic insulin resistance. We have shown previously that acetyl-CoA
carboxylase 2 (Acc2−/−) mutant mice, when fed a high-fat (HF) or high-fat, high-
carbohydrate (HFHC) diet, are protected against diet-induced obesity and maintained whole
body and hepatic insulin sensitivity. To determine the effect of an ACC2 deletion on hepatic
fat metabolism, we studied the regulation of the enzymes involved in the lipogenic pathway�…
hepatic steatosis and hepatic insulin resistance. We have shown previously that acetyl-CoA
carboxylase 2 (Acc2−/−) mutant mice, when fed a high-fat (HF) or high-fat, high-
carbohydrate (HFHC) diet, are protected against diet-induced obesity and maintained whole
body and hepatic insulin sensitivity. To determine the effect of an ACC2 deletion on hepatic
fat metabolism, we studied the regulation of the enzymes involved in the lipogenic pathway�…