Metformin for treatment of fragile X syndrome and other neurological disorders
I Gantois, J Popic, A Khoutorsky…�- Annual review of�…, 2019 - annualreviews.org
Fragile X syndrome (FXS) is the most frequent inherited form of intellectual disability and
autism spectrum disorder. Loss of the fragile X mental retardation protein, FMRP, engenders
molecular, behavioral, and cognitive deficits in FXS patients. Experiments using different
animal models advanced our knowledge of the pathophysiology of FXS and led to the
discovery of many targets for drug treatments. In this review, we discuss the potential of
metformin, an antidiabetic drug approved by the US Food and Drug Administration, to�…
autism spectrum disorder. Loss of the fragile X mental retardation protein, FMRP, engenders
molecular, behavioral, and cognitive deficits in FXS patients. Experiments using different
animal models advanced our knowledge of the pathophysiology of FXS and led to the
discovery of many targets for drug treatments. In this review, we discuss the potential of
metformin, an antidiabetic drug approved by the US Food and Drug Administration, to�…