The regulation and maintenance of systemic iron homeostasis is critical to human health.
Iron overload and deficiency diseases belong to the most common nutrition-related
pathologies across the globe. It is now well appreciated that the hormonal
hepcidin/ferroportin system plays an important regulatory role for systemic iron metabolism.
We review recent data that uncover the importance of the cellular iron-responsive
element/iron-regulatory protein (IRE/IRP) regulatory network in systemic iron homeostasis�…