Elevated prefrontal cortex GABA in patients with major depressive disorder after TMS treatment measured with proton magnetic resonance spectroscopy
Background: GABAergic and glutamatergic neurotransmitter systems are central to the
pathophysiology of depression and are potential targets of repetitive transcranial magnetic
stimulation (rTMS). We assessed the effect of 10-Hz rTMS over the left dorsolateral prefrontal
cortex (DLPFC) of patients with major depressive disorder on the levels of medial prefrontal
cortex (MPFC) γ-aminobutyric acid (GABA) and the combined resonance of glutamate and
glutamine (Glx) as assessed in vivo with proton magnetic resonance spectroscopy (1 H�…
pathophysiology of depression and are potential targets of repetitive transcranial magnetic
stimulation (rTMS). We assessed the effect of 10-Hz rTMS over the left dorsolateral prefrontal
cortex (DLPFC) of patients with major depressive disorder on the levels of medial prefrontal
cortex (MPFC) γ-aminobutyric acid (GABA) and the combined resonance of glutamate and
glutamine (Glx) as assessed in vivo with proton magnetic resonance spectroscopy (1 H�…