The postsynaptic density protein, IQ-ArfGEF/BRAG1, can interact with IRSp53 through its proline-rich sequence
M Sanda, A Kamata, O Katsumata, K Fukunaga…�- Brain research, 2009 - Elsevier
M Sanda, A Kamata, O Katsumata, K Fukunaga, M Watanabe, H Kondo, H Sakagami
Brain research, 2009•ElsevierIQ-ArfGEF/BRAG1, a guanine nucleotide exchange factor for Arf1 and Arf6, is localized at
the postsynaptic density (PSD) and interacts with PSD-95. In this study, we identified a novel
interaction of IQ-ArfGEF/BRAG1 with insulin receptor tyrosine kinase substrate of 53 kDa
(IRSp53), also known as brain-specific angiogenesis inhibitor 1-associated protein 2. The
interaction was mediated by the binding of the C-terminal proline-rich sequence of IQ-
ArfGEF/BRAG1 to the SH3 domain of IRSp53. IQ-ArfGEF/BRAG1 and IRSp53 were�…
the postsynaptic density (PSD) and interacts with PSD-95. In this study, we identified a novel
interaction of IQ-ArfGEF/BRAG1 with insulin receptor tyrosine kinase substrate of 53 kDa
(IRSp53), also known as brain-specific angiogenesis inhibitor 1-associated protein 2. The
interaction was mediated by the binding of the C-terminal proline-rich sequence of IQ-
ArfGEF/BRAG1 to the SH3 domain of IRSp53. IQ-ArfGEF/BRAG1 and IRSp53 were�…
IQ-ArfGEF/BRAG1, a guanine nucleotide exchange factor for Arf1 and Arf6, is localized at the postsynaptic density (PSD) and interacts with PSD-95. In this study, we identified a novel interaction of IQ-ArfGEF/BRAG1 with insulin receptor tyrosine kinase substrate of 53�kDa (IRSp53), also known as brain-specific angiogenesis inhibitor 1-associated protein 2. The interaction was mediated by the binding of the C-terminal proline-rich sequence of IQ-ArfGEF/BRAG1 to the SH3 domain of IRSp53. IQ-ArfGEF/BRAG1 and IRSp53 were colocalized at the PSD of excitatory synapses of certain neuronal populations. Our present findings suggest that IQ-ArfGEF/BRAG1 may play roles downstream of NMDA receptors through the interaction with multivalent PSD proteins such as IRSp53 and PSD-95.
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