[HTML][HTML] Amino acid availability modulates vacuolar H+-ATPase assembly
LA Stransky, M Forgac�- Journal of Biological Chemistry, 2015 - ASBMB
The vacuolar H+-ATPase (V-ATPase) is an ATP-dependent proton pump composed of a
peripheral ATPase domain (V 1) and a membrane-integral proton-translocating domain (V
0) and is involved in many normal and disease processes. An important mechanism of
regulating V-ATPase activity is reversible assembly of the V 1 and V 0 domains. Increased
assembly in mammalian cells occurs under various conditions and has been shown to
involve PI3K. The V-ATPase is necessary for amino acid-induced activation of mechanistic�…
peripheral ATPase domain (V 1) and a membrane-integral proton-translocating domain (V
0) and is involved in many normal and disease processes. An important mechanism of
regulating V-ATPase activity is reversible assembly of the V 1 and V 0 domains. Increased
assembly in mammalian cells occurs under various conditions and has been shown to
involve PI3K. The V-ATPase is necessary for amino acid-induced activation of mechanistic�…