[HTML][HTML] Liproxstatin-1 is an effective inhibitor of oligodendrocyte ferroptosis induced by inhibition of glutathione peroxidase 4
BY Fan, YL Pang, WX Li, CX Zhao…�- Neural regeneration�…, 2021 - journals.lww.com
Our previous studies showed that ferroptosis plays an important role in the acute and
subacute stages of spinal cord injury. High intracellular iron levels and low glutathione
levels make oligodendrocytes vulnerable to cell death after central nervous system trauma.
In this study, we established an oligodendrocyte (OLN-93 cell line) model of ferroptosis
induced by RSL-3, an inhibitor of glutathione peroxidase 4 (GPX4). RSL-3 significantly
increased intracellular concentrations of reactive oxygen species and malondialdehyde�…
subacute stages of spinal cord injury. High intracellular iron levels and low glutathione
levels make oligodendrocytes vulnerable to cell death after central nervous system trauma.
In this study, we established an oligodendrocyte (OLN-93 cell line) model of ferroptosis
induced by RSL-3, an inhibitor of glutathione peroxidase 4 (GPX4). RSL-3 significantly
increased intracellular concentrations of reactive oxygen species and malondialdehyde�…