A hypothesis of synergism: the interrelationship of T3 and insulin to disturbances in metabolic homeostasis
SR Kim, ES Tull, EO Talbott, MT Vogt, LH Kuller�- Medical hypotheses, 2002 - Elsevier
While the role of abnormal insulin homeostasis in the pathogenesis of Type-2 diabetes
mellitus is well established, the importance of the canonical role of T3 on Type-2 diabetes or
the homeostasis of glucose, lipid, and energy balance has not been addressed. Based on
the available evidence from molecular biology, the pivotal regulatory role of T3 in major
metabolic pathways and glycemic control can be delineated by mapping the specific action
sites of T3 and insulin on the metabolic pathways of the glucose–lipid cycle. The current�…
mellitus is well established, the importance of the canonical role of T3 on Type-2 diabetes or
the homeostasis of glucose, lipid, and energy balance has not been addressed. Based on
the available evidence from molecular biology, the pivotal regulatory role of T3 in major
metabolic pathways and glycemic control can be delineated by mapping the specific action
sites of T3 and insulin on the metabolic pathways of the glucose–lipid cycle. The current�…