[HTML][HTML] Estrogen-induced proliferation of uterine epithelial cells is independent of estrogen receptor α binding to classical estrogen response elements
JE O'Brien, TJ Peterson, MH Tong, EJ Lee…�- Journal of Biological�…, 2006 - ASBMB
Acting via the estrogen receptor (ER), estradiol exerts pleomorphic effects on the uterus,
producing cyclical waves of cellular proliferation and differentiation in preparation for
embryo implantation. In the classical pathway, the ER binds directly to an estrogen response
element to activate or repress gene expression. However, emerging evidence supports the
existence of nonclassical pathways in which the activated ER alters gene expression
through protein-protein tethering with transcription factors such as c-Fos/c-Jun B (AP-1) and�…
producing cyclical waves of cellular proliferation and differentiation in preparation for
embryo implantation. In the classical pathway, the ER binds directly to an estrogen response
element to activate or repress gene expression. However, emerging evidence supports the
existence of nonclassical pathways in which the activated ER alters gene expression
through protein-protein tethering with transcription factors such as c-Fos/c-Jun B (AP-1) and�…