Many cellular signaling pathways ultimately control specific patterns of gene expression in
the nucleus through a variety of signal-regulated transcription factors (TFs), including
nuclear hormone receptors (NRs). The advent of genomic technologies for examining signal-
regulated transcriptional responses and TF binding on a genomic scale has dramatically
increased our understanding of the cellular programs that control hormonal signaling and
gene regulation. Studies of TFs, especially NRs, using genomic approaches have revealed�…