Cancers have clonal, aneuploid karyotypes that evolve ever more malignant phenotypes
spontaneously. Because these facts are hard to explain by conventional mutation theory, we
propose here a karyotypic cancer theory. According to this theory, carcinogens initiate
carcinogenesis by inducing random aneuploidy. Aneuploidy then catalyzes karyotypic
evolutions, because it destabilizes the karyotype by unbalancing teams of proteins that
segregate, synthesize, and repair chromosomes. Sporadically, such evolutions generate�…