Postsynaptic density protein 95 (PSD-95), a specialized scaffold protein with multiple protein
interaction domains, forms the backbone of an extensive postsynaptic protein complex that
organizes receptors and signal transduction molecules at the synaptic contact zone. Large,
detergent-insoluble PSD-95-based postsynaptic complexes can be affinity-purified from
conventional PSD fractions using magnetic beads coated with a PSD-95 antibody. In the
present study purified PSD-95 complexes were analyzed by LC/MS/MS. A semiquantitative�…