Ferroptosis is a nonapoptotic, iron-dependent form of cell death that can be activated in
cancer cells by natural stimuli and synthetic agents. Three essential hallmarks define
ferroptosis, namely: the loss of lipid peroxide repair capacity by the phospholipid
hydroperoxidase GPX4, the availability of redox-active iron, and oxidation of
polyunsaturated fatty acid (PUFA)-containing phospholipids. Several processes including
RAS/MAPK signaling, amino acid and iron metabolism, ferritinophagy, epithelial-to�…