Clinical MRI for iron detection in Parkinson's disease
M Rossi, H Ruottinen, S Soimakallio, I Elovaara…�- Clinical imaging, 2013 - Elsevier
We studied nonheme iron in Parkinson's disease (PD) using clinically available MRI in 36
patients and 21 healthy volunteers. The subjects underwent thorough clinical investigation,
including 3-T MRI. Quantitative R2* was able to reflect symptoms of PD. In addition, the
clinically used susceptibility-weighted imaging differentiated between controls and patients,
whereas T2-weighted imaging did not. Disease-related changes were present not only in
substantia nigra but also in globus pallidus. Such changes are associated with�…
patients and 21 healthy volunteers. The subjects underwent thorough clinical investigation,
including 3-T MRI. Quantitative R2* was able to reflect symptoms of PD. In addition, the
clinically used susceptibility-weighted imaging differentiated between controls and patients,
whereas T2-weighted imaging did not. Disease-related changes were present not only in
substantia nigra but also in globus pallidus. Such changes are associated with�…