Could MYC induction of mitochondrial biogenesis be linked to ROS production and genomic instability?
CV Dang, F Li, LA Lee�- Cell cycle, 2005 - Taylor & Francis
CV Dang, F Li, LA Lee
Cell cycle, 2005•Taylor & FrancisMYC has been linked separately to genomic instability and to reactive oxygen species
production, but the connection between these two processes has not been firmly
established. Our recent study along with previous reports demonstrate that Myc induces
nuclear encoded mitochondrial gene expression and mitochondrial biogenesis, thereby
directly associating Myc's transcriptional properties, to the production of mitochondrial ROS
and the promotion of genomic oxidative damage and genomic instability 1.
production, but the connection between these two processes has not been firmly
established. Our recent study along with previous reports demonstrate that Myc induces
nuclear encoded mitochondrial gene expression and mitochondrial biogenesis, thereby
directly associating Myc's transcriptional properties, to the production of mitochondrial ROS
and the promotion of genomic oxidative damage and genomic instability 1.
MYC has been linked separately to genomic instability and to reactive oxygen species production, but the connection between these two processes has not been firmly established. Our recent study along with previous reports demonstrate that Myc induces nuclear encoded mitochondrial gene expression and mitochondrial biogenesis, thereby directly associating Myc’s transcriptional properties, to the production of mitochondrial ROS and the promotion of genomic oxidative damage and genomic instability 1.
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