Mutations in the mitochondrial ATPase6 gene are frequent in human osteosarcoma
XG Guo, CT Liu, H Dai, QN Guo�- Experimental and Molecular Pathology, 2013 - Elsevier
To explore the polymorphisms and mutations of mitochondrial ATPase6 gene in Chinese
patients with osteosarcoma and their possible association with carcinogenesis, direct DNA
sequencing method was used to detect the variants of the mitochondrial ATPase6 gene in
39 patients with osteosarcoma. We found mutations of the mitochondrial ATPase6 gene in
24/39 (61.5%) of the tested osteosarcoma samples, and identified 27 variant sites in
ATPase6 coding regions. We did not detect any new polymorphisms in osteosarcoma, nor�…
patients with osteosarcoma and their possible association with carcinogenesis, direct DNA
sequencing method was used to detect the variants of the mitochondrial ATPase6 gene in
39 patients with osteosarcoma. We found mutations of the mitochondrial ATPase6 gene in
24/39 (61.5%) of the tested osteosarcoma samples, and identified 27 variant sites in
ATPase6 coding regions. We did not detect any new polymorphisms in osteosarcoma, nor�…