Brain metabolic alterations in medication-free patients with bipolardisorder
SR Dager, SD Friedman, A Parow…�- Archives of general�…, 2004 - jamanetwork.com
Background Bipolar disorder (BD) has substantial morbidity and incompletely understood
neurobiological underpinnings. Objective To investigate brain chemistry in medication-free
individuals with BD. Design Two-dimensional proton echo-planar spectroscopic imaging
(PEPSI)(32� 32, 1-cm 3 voxel matrix) acquired axially through the cingulate gyrus was used
to quantify regional brain chemistry. Setting The Center for Anxiety and Depression at the
University of Washington in Seattle and the Bipolar Research Programs at McLean Hospital�…
neurobiological underpinnings. Objective To investigate brain chemistry in medication-free
individuals with BD. Design Two-dimensional proton echo-planar spectroscopic imaging
(PEPSI)(32� 32, 1-cm 3 voxel matrix) acquired axially through the cingulate gyrus was used
to quantify regional brain chemistry. Setting The Center for Anxiety and Depression at the
University of Washington in Seattle and the Bipolar Research Programs at McLean Hospital�…