Cardiovascular health and sexual health have their roots in a healthy endothelium, the most important site of production of nitric oxide (NO) in blood vessels. Our discoveries of the fundamental roles of NO in regulating blood flow, blood pressure, and blood coagulation, as well as functioning as the principal neurotransmitter mediating erectile function, signaled the exploration of the role of NO in penile blood flow, leading to the application of the first oral agent to treat erectile dysfunction. This and other revolutionary contributions to the field in the past 25 years place clinicians at the optimal position to evaluate very carefully the impact of biological as well as psychosocial factors on sexual functioning in addition to integrating biological treatments and psychosocial approaches to improve sexual function and, hence, the quality of life.

The Textbook of Clinical Sexual Medicine utilizes the biopsychosocial approach to inform physicians, practitioners, residents, trainees, and students about the latest that science has to offer for the evaluation and treatment of sexual dysfunctions especially the utilization of the full armamentarium of assessment methods and treatment interventions in order to restore sexual health and enhance quality of life.