The mammary gland is a sensitive pubertal target in CD-1 and C57Bl/6 mice following perinatal perfluorooctanoic acid (PFOA) exposure
DK Tucker, MB Macon, MJ Strynar, S Dagnino…�- Reproductive�…, 2015 - Elsevier
Perfluorooctanoic acid (PFOA) is a developmental toxicant in mice, with varied strain
outcomes depending on dose and period of exposure. The impact of PFOA on female
mouse pubertal development at low doses (≤ 1 mg/kg) has yet to be determined. Therefore,
female offspring from CD-1 and C57Bl/6 dams exposed to PFOA, creating serum
concentrations similar to humans, were examined for pubertal onset, including mammary
gland development. Pups demonstrated a shorter PFOA elimination half-life than that�…
outcomes depending on dose and period of exposure. The impact of PFOA on female
mouse pubertal development at low doses (≤ 1 mg/kg) has yet to be determined. Therefore,
female offspring from CD-1 and C57Bl/6 dams exposed to PFOA, creating serum
concentrations similar to humans, were examined for pubertal onset, including mammary
gland development. Pups demonstrated a shorter PFOA elimination half-life than that�…