Childhood adversity and neural development: A systematic review
KA McLaughlin, D Weissman…�- Annual review of�…, 2019 - annualreviews.org
An extensive literature on childhood adversity and neurodevelopment has emerged over the
past decade. We evaluate two conceptual models of adversity and neurodevelopment—the
dimensional model of adversity and stress acceleration model—in a systematic review of
109 studies using MRI-based measures of neural structure and function in children and
adolescents. Consistent with the dimensional model, children exposed to threat had
reduced amygdala, medial prefrontal cortex (mPFC), and hippocampal volume and�…
past decade. We evaluate two conceptual models of adversity and neurodevelopment—the
dimensional model of adversity and stress acceleration model—in a systematic review of
109 studies using MRI-based measures of neural structure and function in children and
adolescents. Consistent with the dimensional model, children exposed to threat had
reduced amygdala, medial prefrontal cortex (mPFC), and hippocampal volume and�…