[HTML][HTML] Accumulation of vitamin C (ascorbate) and its oxidized metabolite dehydroascorbic acid occurs by separate mechanisms
RW Welch, Y Wang, A Crossman, JB Park…�- Journal of Biological�…, 1995 - ASBMB
It is unknown whether ascorbate alone (vitamin C), its oxidized metabolite dehydroascorbic
acid alone, or both species are transported into human cells. This problem was addressed
using specific assays for each compound, freshly synthesized pure dehydroascorbic acid,
the specially synthesized analog 6-chloroascorbate, and a new assay for 6-chloroascorbate.
Ascorbate and dehydroascorbic acid were transported and accumulated distinctly; neither
competed with the other. Ascorbate was accumulated as ascorbate by sodium-dependent�…
acid alone, or both species are transported into human cells. This problem was addressed
using specific assays for each compound, freshly synthesized pure dehydroascorbic acid,
the specially synthesized analog 6-chloroascorbate, and a new assay for 6-chloroascorbate.
Ascorbate and dehydroascorbic acid were transported and accumulated distinctly; neither
competed with the other. Ascorbate was accumulated as ascorbate by sodium-dependent�…