Multinuclear magnetic resonance spectroscopy of high-energy phosphate metabolites in human brain following oral supplementation of creatine-monohydrate
IK Lyoo, SW Kong, SM Sung, F Hirashima…�- Psychiatry Research�…, 2003 - Elsevier
Alterations in brain high-energy phosphate metabolism, determined by in vivo magnetic
resonance spectroscopy (MRS), have been reported in subjects with a number of brain
disorders including major depression, schizophrenia, and substance abuse. It is not clear to
what extent these changes can be modified by pharmacological or nutritional means. To
address this possibility, we evaluated changes in brain chemistry that were associated with
oral creatine (Cr) administration. We hypothesized that oral Cr supplementation, by�…
resonance spectroscopy (MRS), have been reported in subjects with a number of brain
disorders including major depression, schizophrenia, and substance abuse. It is not clear to
what extent these changes can be modified by pharmacological or nutritional means. To
address this possibility, we evaluated changes in brain chemistry that were associated with
oral creatine (Cr) administration. We hypothesized that oral Cr supplementation, by�…