How mitotic errors contribute to karyotypic diversity in cancer
JM Nicholson, D Cimini�- Advances in cancer research, 2011 - Elsevier
Aneuploidy is a common feature of cancer cells, and is believed to play a critical role in
tumorigenesis and cancer progression. Most cancer cells also exhibit high rates of mitotic
chromosome mis-segregation, a phenomenon known as chromosomal instability, which
leads to high variability of the karyotype. Here, we describe the nature, nuances, and
implications of cancer karyotypic diversity. Moreover, we summarize recent studies aimed at
identifying the mitotic defects that may be responsible for inducing chromosome mis�…
tumorigenesis and cancer progression. Most cancer cells also exhibit high rates of mitotic
chromosome mis-segregation, a phenomenon known as chromosomal instability, which
leads to high variability of the karyotype. Here, we describe the nature, nuances, and
implications of cancer karyotypic diversity. Moreover, we summarize recent studies aimed at
identifying the mitotic defects that may be responsible for inducing chromosome mis�…