Somatic mutations of mitochondrial genome in hepatocellular carcinoma
PH Yin, CC Wu, JC Lin, CW Chi, YH Wei, HC Lee�- Mitochondrion, 2010 - Elsevier
Somatic mutations have been identified in mitochondrial DNA (mtDNA) of various human
primary cancers. However, their roles in the pathophysiology of cancers are still unclear. In
our previous study, high frequency of somatic mutations was found in the D-loop region of
mtDNA of hepatocellular carcinomas (HCCs). In the present study, we examined 44 HCCs
and corresponding non-cancerous liver tissues, and identified 13 somatic mutations in the
coding region of mtDNAs from 11 HCC samples (11/44, 25%). Among the 13 mtDNA�…
primary cancers. However, their roles in the pathophysiology of cancers are still unclear. In
our previous study, high frequency of somatic mutations was found in the D-loop region of
mtDNA of hepatocellular carcinomas (HCCs). In the present study, we examined 44 HCCs
and corresponding non-cancerous liver tissues, and identified 13 somatic mutations in the
coding region of mtDNAs from 11 HCC samples (11/44, 25%). Among the 13 mtDNA�…