Mediation of the relationship between maternal phthalate exposure and preterm birth by oxidative stress with repeated measurements across pregnancy
Background: Mediation analysis is useful for understanding mechanisms and has been
used minimally in the study of the environment and disease. Objective: We examined
mediation of the association between phthalate exposure during pregnancy and preterm
birth by oxidative stress. Methods: This nested case–control study of preterm birth (n= 130
cases, 352 controls) included women who delivered in Boston, Massachusestts, from 2006
through 2008. Phthalate metabolites and 8-isoprostane, an oxidative stress biomarker, were�…
used minimally in the study of the environment and disease. Objective: We examined
mediation of the association between phthalate exposure during pregnancy and preterm
birth by oxidative stress. Methods: This nested case–control study of preterm birth (n= 130
cases, 352 controls) included women who delivered in Boston, Massachusestts, from 2006
through 2008. Phthalate metabolites and 8-isoprostane, an oxidative stress biomarker, were�…