Effectors of mTOR-autophagy pathway: targeting cancer, affecting the skeleton
AS Chagin�- Current Opinion in Pharmacology, 2016 - Elsevier
Highlights•Autophagy in epiphyseal chondrocytes facilitates longitudinal bone
growth.•Autophagy in articular chondrocytes protects against development of osteoarthritis.•
Autophagy in osteoblasts promotes their differentiation and maintains bone
mass.•Autophagy in osteoclasts facilitates both their differentiation and
osteoporosis.Although some modulators of autophagy are emerging as drugs or
supplements for anti-cancer therapy, the effects of these compounds on normal tissues must�…
growth.•Autophagy in articular chondrocytes protects against development of osteoarthritis.•
Autophagy in osteoblasts promotes their differentiation and maintains bone
mass.•Autophagy in osteoclasts facilitates both their differentiation and
osteoporosis.Although some modulators of autophagy are emerging as drugs or
supplements for anti-cancer therapy, the effects of these compounds on normal tissues must�…