Therapeutic and nutraceutical potential of rosmarinic acid—Cytoprotective properties and pharmacokinetic profile
S Nunes, AR Madureira, D Campos…�- Critical reviews in�…, 2017 - Taylor & Francis
Critical reviews in food science and nutrition, 2017•Taylor & Francis
Rosmarinic acid (RA) is a natural polyphenolic antioxidant derived from many common
herbal plants. This compound displays several important biological properties, including anti-
inflammatory, antiviral, antibacterial, antidepressant, anticarcionogenic, and
chemopreventive properties. The importance of its activities and its possible application in
processed foods as a natural antioxidant has reached a new interest levels in recent years.
The health effects of this polyphenol depend greatly on both its intakes and bioavailability�…
herbal plants. This compound displays several important biological properties, including anti-
inflammatory, antiviral, antibacterial, antidepressant, anticarcionogenic, and
chemopreventive properties. The importance of its activities and its possible application in
processed foods as a natural antioxidant has reached a new interest levels in recent years.
The health effects of this polyphenol depend greatly on both its intakes and bioavailability�…
Abstract
Rosmarinic acid (RA) is a natural polyphenolic antioxidant derived from many common herbal plants. This compound displays several important biological properties, including anti-inflammatory, antiviral, antibacterial, antidepressant, anticarcionogenic, and chemopreventive properties. The importance of its activities and its possible application in processed foods as a natural antioxidant has reached a new interest levels in recent years. The health effects of this polyphenol depend greatly on both its intakes and bioavailability. This review focuses on the importance of RA as a dietary supplement, and summarizes its pharmacokinetics and metabolism, including the factors that limit its oral bioavailability which leads to a lower therapeutic action. Further experimental investigations are needed to optimize and enhance the oral bioavailability of this natural compound which consequently will help increasing therapeutic efficacy of RA in vivo.
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