Regulation of mammalian target of rapamycin complex 1 (mTORC1) by hypoxia: causes and consequences
H Cam, PJ Houghton�- Targeted oncology, 2011 - Springer
H Cam, PJ Houghton
Targeted oncology, 2011•SpringerIntegration of cellular and extracellular signals maintains tissue homeostasis under
conditions of normal proliferation and stress. A central player in regulating responses to
stress is the serine/threonine kinase mammalian target of rapamycin (mTOR). In many
cancers, mTOR complex 1 (mTORC1) signaling is enhanced, even under conditions where
such signaling should be suppressed. This article reviews some of the details that are
emerging on how low oxygen (hypoxia) regulates mTORC1 signaling, and the�…
conditions of normal proliferation and stress. A central player in regulating responses to
stress is the serine/threonine kinase mammalian target of rapamycin (mTOR). In many
cancers, mTOR complex 1 (mTORC1) signaling is enhanced, even under conditions where
such signaling should be suppressed. This article reviews some of the details that are
emerging on how low oxygen (hypoxia) regulates mTORC1 signaling, and the�…
Abstract
Integration of cellular and extracellular signals maintains tissue homeostasis under conditions of normal proliferation and stress. A central player in regulating responses to stress is the serine/threonine kinase mammalian target of rapamycin (mTOR). In many cancers, mTOR complex 1 (mTORC1) signaling is enhanced, even under conditions where such signaling should be suppressed. This article reviews some of the details that are emerging on how low oxygen (hypoxia) regulates mTORC1 signaling, and the consequences for dysregulation in pediatric solid tumors.
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