Red wine polyphenols influence carcinogenesis, intestinal microflora, oxidative damage and gene expression profiles of colonic mucosa in F344 rats
P Dolara, C Luceri, C De Filippo, AP Femia…�- Mutation Research�…, 2005 - Elsevier
Polyphenols from tea and other beverages such as red wine have been regarded with
interest as possible chemopreventive agents against cancer. Here we report that red wine
polyphenols (50mg/kg) administered with the diet to F344 rats for 16 weeks inhibited colon
carcinogenesis induced by azoxymethane (AOM, 7.4 mg/kg, total dose 74mg/kg) or
dimethylhydrazine (DMH, 30mg/kg, total dose, 300mg/kg). Polyphenol-treated animals had
a consistently lower tumour yield compared to controls. In polyphenol-treated rats, the main�…
interest as possible chemopreventive agents against cancer. Here we report that red wine
polyphenols (50mg/kg) administered with the diet to F344 rats for 16 weeks inhibited colon
carcinogenesis induced by azoxymethane (AOM, 7.4 mg/kg, total dose 74mg/kg) or
dimethylhydrazine (DMH, 30mg/kg, total dose, 300mg/kg). Polyphenol-treated animals had
a consistently lower tumour yield compared to controls. In polyphenol-treated rats, the main�…