Maternal autism-associated IgG antibodies delay development and produce anxiety in a mouse gestational transfer model
D Braunschweig, MS Golub, CM Koenig, L Qi…�- Journal of�…, 2012 - Elsevier
A murine passive transfer model system was employed to ascertain the effects of gestational
exposure to a single, intravenous dose of purified, brain-reactive IgG antibodies from
individual mothers of children with autism (MAU) or mothers with typically developing
children (MTD). Growth and behavioral outcomes in offspring were measured from postnatal
days 8 to 65 in each group. Comparisons revealed alterations in early growth trajectories,
significantly impaired motor and sensory development, and increased anxiety. This report�…
exposure to a single, intravenous dose of purified, brain-reactive IgG antibodies from
individual mothers of children with autism (MAU) or mothers with typically developing
children (MTD). Growth and behavioral outcomes in offspring were measured from postnatal
days 8 to 65 in each group. Comparisons revealed alterations in early growth trajectories,
significantly impaired motor and sensory development, and increased anxiety. This report�…