Age-related decline in dopamine transporters: analysis of striatal subregions, nonlinear effects, and hemispheric asymmetries
CH van Dyck, JP Seibyl, RT Malison, M Laruelle…�- The American journal of�…, 2002 - Elsevier
Neuroimaging studies have documented an age-related decline in striatal dopamine
transporters (DATs) as a marker of dopaminergic neurodegeneration. The authors further
elucidated the effects on this neural system in healthy aging, in contrast to Parkinson
disease (PD). The effects of age on striatal DAT availability were examined in a large,
healthy subject sample (N= 126) with [123 I] 2β-carbomethoxy-3β-(4-iodophenyl) tropane
([123 I] β-CIT) and single photon emission computed tomography (SPECT). Striatal DAT�…
transporters (DATs) as a marker of dopaminergic neurodegeneration. The authors further
elucidated the effects on this neural system in healthy aging, in contrast to Parkinson
disease (PD). The effects of age on striatal DAT availability were examined in a large,
healthy subject sample (N= 126) with [123 I] 2β-carbomethoxy-3β-(4-iodophenyl) tropane
([123 I] β-CIT) and single photon emission computed tomography (SPECT). Striatal DAT�…