Importance Major depressive disorder (MDD) remains challenging to treat. Although several
clinical and demographic variables have been found to predict poor antidepressant
response, these markers have not been robustly replicated to warrant implementation in
clinical care. Increased pretreatment rostral anterior cingulate cortex (rACC) theta activity
has been linked to better antidepressant outcomes. However, no prior study has evaluated
whether this marker has incremental predictive validity over clinical and demographic�…