Reduced density of calbindin immunoreactive GABAergic neurons in the occipital cortex in major depression: relevance to neuroimaging studies
D Maciag, J Hughes, G O'Dwyer, Y Pride…�- Biological�…, 2010 - Elsevier
BACKGROUND: Several lines of evidence suggest dysfunction of the γ-aminobutyric acid
(GABA) ergic system in major depressive disorder. Neuroimaging studies report reduced
levels of GABA in the dorsolateral prefrontal and occipital cortex of depressed patients. Our
previous postmortem study revealed a reduction in the density and size of calbindin-
immunoreactive (CB-IR) GABAergic neurons in the prefrontal cortex in major depressive
disorder. The goal of this study was to test whether the changes in CB-IR neurons can also�…
(GABA) ergic system in major depressive disorder. Neuroimaging studies report reduced
levels of GABA in the dorsolateral prefrontal and occipital cortex of depressed patients. Our
previous postmortem study revealed a reduction in the density and size of calbindin-
immunoreactive (CB-IR) GABAergic neurons in the prefrontal cortex in major depressive
disorder. The goal of this study was to test whether the changes in CB-IR neurons can also�…