Perfluorooctanoic acid effects on ovaries mediate its inhibition of peripubertal mammary gland development in Balb/c and C57Bl/6 mice
Y Zhao, YS Tan, MJ Strynar, G Perez, SZ Haslam…�- Reproductive�…, 2012 - Elsevier
Exposure to perfluorooctanoic acid (PFOA), a synthetic perfluorinated compound and an
agonist of peroxisome proliferator-activated receptor α (PPARα), causes stunted mouse
mammary gland development in various developmental stages. However, the underlying
mechanisms remain poorly understood. We found that peripubertal PFOA exposure
significantly inhibited mammary gland growth in both Balb/c and C57Bl/6 wild type mice, but
not in C57Bl/6 PPARα knockout mice, and Balb/c mice were more sensitive to PFOA�…
agonist of peroxisome proliferator-activated receptor α (PPARα), causes stunted mouse
mammary gland development in various developmental stages. However, the underlying
mechanisms remain poorly understood. We found that peripubertal PFOA exposure
significantly inhibited mammary gland growth in both Balb/c and C57Bl/6 wild type mice, but
not in C57Bl/6 PPARα knockout mice, and Balb/c mice were more sensitive to PFOA�…