Risk for premenstrual dysphoric disorder is associated with genetic variation in ESR1, the estrogen receptor alpha gene
L Huo, RE Straub, C Roca, PJ Schmidt, K Shi…�- Biological�…, 2007 - Elsevier
BACKGROUND: Premenstrual dysphoric disorder (PMDD) is a heritable mood disorder that
is triggered by gonadal steroids during the luteal phase in susceptible women. METHODS:
We performed haplotype analyses of estrogen receptors alpha and beta (ESR1 and ESR2)
in 91 women with prospectively confirmed PMDD and 56 control subjects to investigate
possible sources of the genetic susceptibility to affective dysregulation induced by normal
levels of gonadal steroids. We also examined associations with the valine (Val)�…
is triggered by gonadal steroids during the luteal phase in susceptible women. METHODS:
We performed haplotype analyses of estrogen receptors alpha and beta (ESR1 and ESR2)
in 91 women with prospectively confirmed PMDD and 56 control subjects to investigate
possible sources of the genetic susceptibility to affective dysregulation induced by normal
levels of gonadal steroids. We also examined associations with the valine (Val)�…