Alterations in brain transition metals in Huntington disease: an evolving and intricate story
HD Rosas, YI Chen, G Doros, DH Salat…�- Archives of�…, 2012 - jamanetwork.com
Background Aberrant accumulation of transition metals in the brain may have an early and
important role in the pathogenesis of several neurodegenerative disorders, including
Huntington disease (HD). Objective To comprehensively evaluate and validate the
distribution of metal deposition in the brain using advanced magnetic resonance imaging
methods from the premanifest through symptomatic stages of HD. Design Observational
study. Setting University imaging center. Participants Twenty-eight HD expanded gene�…
important role in the pathogenesis of several neurodegenerative disorders, including
Huntington disease (HD). Objective To comprehensively evaluate and validate the
distribution of metal deposition in the brain using advanced magnetic resonance imaging
methods from the premanifest through symptomatic stages of HD. Design Observational
study. Setting University imaging center. Participants Twenty-eight HD expanded gene�…