Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack
MR Brown, J Kronengold, VR Gazula, Y Chen…�- Nature�…, 2010 - nature.com
MR Brown, J Kronengold, VR Gazula, Y Chen, JG Strumbos, FJ Sigworth, D Navaratnam…
Nature neuroscience, 2010•nature.comIn humans, the absence of Fragile X mental retardation protein (FMRP), an RNA-binding
protein, results in Fragile X syndrome, the most common inherited form of intellectual
disability. Using biochemical and electrophysiological studies, we found that FMRP binds to
the C terminus of the Slack sodium-activated potassium channel to activate the channel in
mice. Our findings suggest that Slack activity provides a link between patterns of neuronal
firing and changes in protein translation.
protein, results in Fragile X syndrome, the most common inherited form of intellectual
disability. Using biochemical and electrophysiological studies, we found that FMRP binds to
the C terminus of the Slack sodium-activated potassium channel to activate the channel in
mice. Our findings suggest that Slack activity provides a link between patterns of neuronal
firing and changes in protein translation.
Abstract
In humans, the absence of Fragile X mental retardation protein (FMRP), an RNA-binding protein, results in Fragile X syndrome, the most common inherited form of intellectual disability. Using biochemical and electrophysiological studies, we found that FMRP binds to the C terminus of the Slack sodium-activated potassium channel to activate the channel in mice. Our findings suggest that Slack activity provides a link between patterns of neuronal firing and changes in protein translation.
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