BACKGROUND: Low cerebral bioenergetic metabolism has been reported in subjects with
major depressive disorder (MDD). Thyroid hormones have been shown to increase brain
bioenergetic metabolism. We assessed whether changes in brain bioenergetics measured
with phosphorus magnetic resonance spectroscopy (31P MRS) correlate with treatment
outcome during augmentation treatment with triiodothyronine (T3) in MDD. METHODS:
Nineteen subjects meeting DSM-IV criteria for MDD who had previously failed to respond to�…