[HTML][HTML] Fosgonimeton, a novel positive modulator of the HGF/MET system, promotes neurotrophic and procognitive effects in models of dementia
JL Johnston, SM Reda, SE Setti, RW Taylor…�- …, 2023 - Elsevier
All types of dementia, including Alzheimer's disease, are debilitating neurodegenerative
conditions marked by compromised cognitive function for which there are few effective
treatments. Positive modulation of hepatocyte growth factor (HGF)/MET, a critical
neurotrophic signaling system, may promote neuronal health and function, thereby
addressing neurodegeneration in dementia. Here, we evaluate a series of novel small
molecules for their ability to (1) positively modulate HGF/MET activity,(2) induce neurotrophic�…
conditions marked by compromised cognitive function for which there are few effective
treatments. Positive modulation of hepatocyte growth factor (HGF)/MET, a critical
neurotrophic signaling system, may promote neuronal health and function, thereby
addressing neurodegeneration in dementia. Here, we evaluate a series of novel small
molecules for their ability to (1) positively modulate HGF/MET activity,(2) induce neurotrophic�…