Co-active coping is a fundamental construct in organizational and work environments as it allows for the exploration of individual and group behaviors within organizations. The aim of this study was to develop a new scale called the Co-Active Coping Inventory in the Chilean context. The sample was comprised of 1,442 workers with an average age of 30.48 years (SD = 11.13). 55% were public-sector workers, 34.5% were workers in private commercial organizations, and 10.5% belonged to non-profit private organizations. Different exploratory factor analyses were performed, and the best exploratory model was verified with a confirmatory factor analysis. In addition, multiple linear regressions were used to analyze which dimensions of co-active coping helped predict workers’ burnout (emotional exhaustion, affective hardening, and personal fulfillment) and symptomatology (psychological and somatic). Based on the exploratory and confirmatory approach, the Co-Active Coping Inventory showed a good fit to a structure of five correlated factors (Reflective Action, Rash Action, Search for Spiritual Support, Search for Affective Support and Evasion), demonstrating measurement invariance in terms of sex and type of organization. The different domains of co-active coping explain between 20% (emotional exhaustion) and 41% (affective hardening) of occupational burnout and around 3–5% of workers’ symptomatology, with reflective action being the most important variable. These results indicate that the new scale has suitable psychometric properties; it can assess coping strategies in the Chilean organizational context in a reliable and valid way. These coping strategies have demonstrated certain importance in relation to organizational and clinical variables.