The immunomodulatory role of the hypothalamus-pituitary-gonad axis: proximate mechanism for reproduction-immune trade offs?
H Segner, BML Verburg-van Kemenade…�- Developmental &�…, 2017 - Elsevier
The present review discusses the communication between the hypothalamic-pituitary-gonad
(HPG) axis and the immune system of vertebrates, attempting to situate the HPG-immune
interaction into the context of life history trade-offs between reproductive and immune
functions. More specifically,(i) we review molecular and cellular interactions between
hormones of the HPG axis, and, as far as known, the involved mechanisms on immune
functions,(ii) we evaluate whether the HPG-immune crosstalk serves as proximate�…
(HPG) axis and the immune system of vertebrates, attempting to situate the HPG-immune
interaction into the context of life history trade-offs between reproductive and immune
functions. More specifically,(i) we review molecular and cellular interactions between
hormones of the HPG axis, and, as far as known, the involved mechanisms on immune
functions,(ii) we evaluate whether the HPG-immune crosstalk serves as proximate�…