Background Evidence indicates that oxytocin, an endogenous peptide well known for its role
in social behaviors, childbirth, and lactation, is a promising addiction pharmacotherapy. We
employed a within-session behavioral-economic (BE) procedure in rats to examine oxytocin
as a pharmacotherapy for methamphetamine (meth) addiction. The BE paradigm was
modeled after BE procedures used to assess motivation for drugs in humans with addiction.
The same BE variables assessed across species have been shown to predict later relapse�…