Sexually dimorphic role of G protein-coupled estrogen receptor (GPER) in modulating energy homeostasis

KE Davis, EJ Carstens, BG Irani, LM Gent…�- Hormones and�…, 2014 - Elsevier
This article is part of a Special Issue “Energy Balance”. The classical estrogen receptors,
estrogen receptor-α and estrogen receptor-β are well established in the regulation of body
weight and energy homeostasis in both male and female mice, whereas, the role for G
protein-coupled estrogen receptor 1 (GPER) as a modulator of energy homeostasis remains
controversial. This study sought to determine whether gene deletion of GPER (GPER KO)
alters body weight, body adiposity, food intake, and energy homeostasis in both males and�…