[HTML][HTML] Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network
M Brajenovic, G Joberty, B Küster…�- Journal of Biological�…, 2004 - ASBMB
The polarization of eukaryotic cells is controlled by the concerted activities of asymmetrically
localized proteins. The PAR proteins, first identified in Caenorhabditis elegans, are common
regulators of cell polarity conserved from nematode and flies to man. However, little is
known about the molecular mechanisms by which these proteins and protein complexes
establish cell polarity in mammals. We have mapped multiprotein complexes formed around
the putative human Par orthologs MARK4 (microtubule-associated protein/microtubule�…
localized proteins. The PAR proteins, first identified in Caenorhabditis elegans, are common
regulators of cell polarity conserved from nematode and flies to man. However, little is
known about the molecular mechanisms by which these proteins and protein complexes
establish cell polarity in mammals. We have mapped multiprotein complexes formed around
the putative human Par orthologs MARK4 (microtubule-associated protein/microtubule�…