Different striatal dopamine D2 receptor occupancy in alcohol dependent patients with or without physical withdrawal symptoms–a study using IBZM-SPECT
D Ebert, T Klein, C Lohrmann, LT van Elst…�- Journal of neural�…, 2002 - Springer
D Ebert, T Klein, C Lohrmann, LT van Elst, B Hesslinger, FD Juengling
Journal of neural transmission, 2002•SpringerTen male patients with type I alcohol dependency fulfilling DSM-IV criteria for alcohol
dependency were investigated twice using IBZM-SPECT after alcohol withdrawal (day 2 and
day 28 after withdrawal). Five patients had a history of physical withdrawal symptoms, 5
patients had no such history. The group with physical withdrawal symptoms showed higher
IBZM binding in both scans indicating differences of dopaminergic neurotransmission in
different subtypes of alcohol dependency.
dependency were investigated twice using IBZM-SPECT after alcohol withdrawal (day 2 and
day 28 after withdrawal). Five patients had a history of physical withdrawal symptoms, 5
patients had no such history. The group with physical withdrawal symptoms showed higher
IBZM binding in both scans indicating differences of dopaminergic neurotransmission in
different subtypes of alcohol dependency.
Summary
Ten male patients with type I alcohol dependency fulfilling DSM-IV criteria for alcohol dependency were investigated twice using IBZM-SPECT after alcohol withdrawal (day 2 and day 28 after withdrawal). Five patients had a history of physical withdrawal symptoms, 5 patients had no such history. The group with physical withdrawal symptoms showed higher IBZM binding in both scans indicating differences of dopaminergic neurotransmission in different subtypes of alcohol dependency.
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