[HTML][HTML] Structural requirements for TLR4-mediated LPS signalling: a biological role for LPS modifications
F B�ckhed, S Normark, EKH Schweda, S Oscarson…�- Microbes and�…, 2003 - Elsevier
Cells of the mucosal lining are the first to encounter invading bacteria during infection, and
as such, they have developed numerous ways of detecting microbial intruders. Recently, we
showed that epithelial cells recognize lipopolysaccharide (LPS) through the CD14-Toll-like
receptor (TLR)-4 complex. Here, we identify the substructures of LPS that are recognized by
the TLR4 receptor complex. In contrast to lipid A, the O-antigen does not mediate an
inflammatory response; rather it interferes with the lipid A recognition. An Escherichia coli�…
as such, they have developed numerous ways of detecting microbial intruders. Recently, we
showed that epithelial cells recognize lipopolysaccharide (LPS) through the CD14-Toll-like
receptor (TLR)-4 complex. Here, we identify the substructures of LPS that are recognized by
the TLR4 receptor complex. In contrast to lipid A, the O-antigen does not mediate an
inflammatory response; rather it interferes with the lipid A recognition. An Escherichia coli�…